Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Antagonized uricosuric action by salicylates, pyrazinamide. Drug Interactions . It is used to prevent attacks related to gout, not treat them once they occur. Approximately 70 to 85% of the VISTIDE dose administered with concomitant probenecid was excreted as unchanged drug within 24 hr. Penicillin G is distributed to most areas of the body including lung, liver, kidney, muscle, ... Probenecid: Concomitant administration of PRIMAXIN and ... administer additional antagonist as directed by the product’s prescribing information. HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use MOXATAG safely and effectively. Probenecid Probenecid may increase the therapeutic effectiveness of acetaminophen slightly. Therapeutic uses, prescribing information and product availability may vary between countries. Not known if distributed into breast milk, use with caution. administered with probenecid, after one hr infusions of 3.0 (n = 12), 5.0 (n = 6), and 7.5 (n = 4) mg/kg (See Table 2). Probenecid decreases the renal tubular secretion of ampicillin and sulbactam. Prolonged or enhanced action of oral sulfonylureas. Concurrent use of MOXATAG and probenecid may result in increased and Concurrent use of probenecid with UNASYN may result in increased and prolonged blood levels of ampicillin and sulbactam. Click to view SW Probenecid detailed prescribing information. Therefore, the concurrent administration of probenecid prolongs the elimination of penicillin G and, consequently, increases the serum concentrations. It acts on the kidneys to help the body eliminate uric acid. Disclaimer: This information is independently developed by MIMS based on Probenecid from various references and is provided for your reference only. Probenecid is used to treat chronic gout and gouty arthritis. Pregnancy Categories. Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including lorazepam. When VISTIDE was administered with probenecid, the renal clearance of cidofovir Psychic disturbances w/ penicillin or other β-lactams. Probenecid blocks the renal tubular secretion of penicillin. The effects of probenecid and valproate on lorazepam may be due to inhibition of glucuronidation. HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use ... Co-administration with probenecid inhibits the renal excretion of ertapenemandis therefore not recommended. A reduction in dose must be made for a patient with a creatinine clearance of less than 90mL/min(2.3). Probenecid crosses placenta barrier and appears in cord blood; the use of any drug in women of childbearing potential requires that the anticipated benefit be weighed against possible hazards. Lactation. (7.1) The concomitant use of ertapenem and valproic acid/divalproex See full prescribing information for dosage recommendations in pediatric patients (2.2). Limitations of Use. Full Prescribing Information DESCRIPTION ... with probenecid. In an individual physically dependent on opioids, administration of the recommended usual dosage of the antagonist will precipitate an acute withdrawal syndrome. See full prescribing information for ... Probenecid decreases the renal tubular secretion of amoxicillin. INDICATION *BELBUCA ® (buprenorphine buccal film) is indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.. Probenecid is also used to make certain antibiotics more effective by preventing the body from passing them in the urine.