Consumer; Professional; For the Consumer. Schedule your appointment now for safe in-person care. Check with your doctor immediately if any of the following side effects occur: Check with your doctor as soon as possible if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Mayo Clinic does not endorse companies or products. These side effects may go away during treatment as your body adjusts to the medicine. What is the effect of Probenecid on the Heart? [Ref], Frequency not reported: Anaphylaxis, Stevens-Johnson syndrome, urticaria, pruritus[Ref], Frequency not provided: Precipitation of acute gouty arthritis[Ref], Frequency not reported: Uric acid stones with or without hematuria, costovertebral pain, urinary frequency[Ref], Frequency not reported: Nephrotic syndrome, with or without renal failure[Ref], Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency may increase the risk of probenecid-induced hemolytic anemia in some patients. Check with your doctor immediately if any of the following side effects occur: Rare. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: In therapeutic doses, probenecid is generally well tolerated and has a low incidence of side effects. Call up a medical professional at the same time when you've got an important side-effect including: Applies to probenecid: oral tablet. Your doctor may also instruct you on how to decrea… It acts on the kidney to pass uric acid in the urine. Last updated on Nov 20, 2020. Do not treat yourself for headaches or pain. Probenecid and colchicine will not cure gout and it will not stop a gout attack that has already started. Therapeutic uses, prescribing information and product availability may vary between countries. Some side effects may not be reported. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Precautions Before taking probenecid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Marlex Pharmaceuticals, New Castle, DE. O 0. Scott JT, O'Brien PK "Probenecid, nephrotic syndrome, and renal failure." To prevent gout, take this medication by mouth, usually twice daily with food or antacids to reduce stomach upset or as directed by your doctor. Acquire urgent health care guide if you have such clues connected with an allergic reaction: urticaria; lack of breath; bloating within your facial area, mouth, glossa, or maybe neck.. Probenecid may cause harmful effects on the heart. Some of the side-effects may be rare but serious. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. generic drugs or brand names) are also considered. If experienced, these tend to have a Less Severe expression 1. Ask your doctor or health care professional for advice. Check with your doctor immediately if any of the following side effects occur: Rare. What are the possible side effects of probenecid (Benemid)? Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer — Mayo Clinic Health Letter, Time running out - 40% off Online Mayo Clinic Diet ends soon. Other drugs that have the same active ingredients (e.g. Probenecid is also used to increase the blood levels of penicillin-type antibiotics used for the treatment of gonorrhea. Like all medicines, probenecid can cause side effects, although not everyone gets them. The most common side effects of Probenecid are liver problems, nausea, gout flares, joint pain, and rash. In both cases, serum antibodies reacted with red blood cells only in the presence of probenecid. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. experience any side effects. Theoretically probenecid can increase the risk of uric acid kidney stones. These side-effects are possible, but do not always occur. Drug information provided by: IBM Micromedex. Description: Probenecid competitively inhibits the reabsorption of uric acid at the proximal convoluted tubule, thereby promoting its excretion and reducing serum uric acid levels. Probenecid and colchicine is available in generic form. If you notice any other effects, check with your healthcare professional. Probenecid belongs to the class of medications called uricosurics. Check with your doctor immediately if any of the following side effects occur while taking probenecid: Check with your doctor as soon as possible if any of the following side effects occur while taking probenecid: Some side effects of probenecid may occur that usually do not need medical attention. It is not useful for treatment of a gout attack that is currently taking place. If you are on restricted fluid intake, consult your doctor for further instructions. Common side effects include death among females and myocardial infarction among males. It can be harmful for patients to take this medicine without the doctor's advice. Cerner Multum, Inc. "Australian Product Information." When you are taking Probenecid, it is very important that your doctors know if you are taking any other medicine. Medically reviewed by Drugs.com. Cefadroxil + Probenecid is a prescription drug and an antibiotic, hence do not take this drug without consulting doctor to avoid bacterial resistance and unpleasant side effects. Probenecid acts by decreasing levels of uric acid, which causes gout, in the blood. Your prescriber or health care professional will prescribe other tablets to treat an acute attack. Ask your doctor or pharmacist for more information. How To Use. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. You may need periodic blood checks. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Review side effects, dosage, warnings and precautions, and drug interactions prior to taking this medication. Side effects are reported by people who take Probenecid. You may report side effects to the FDA at 1-800-FDA-1088. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. However, probenecid has also been implicated in at least two cases of immune-mediated hemolytic anemia. Probenecid Side Effects. If you observe any side effects on your body then stop taking this drug. Copyright © 2021 IBM Watson Health. Probenecid systemic 500 mg (MYLAN 156 500), We comply with the HONcode standard for trustworthy health information -, puffiness or swellings of the eyelids or around the eyes, shortness of breath, troubled breathing, tightness in chest, or wheezing, changes in the skin color of the face occurring together with any of the other side effects listed here, lower back or side pain (especially if severe or sharp), skin rash, hives, or itching (occurring without other signs of an allergic reaction), sores, ulcers, or white spots on lips or in mouth, swelling of face, fingers, feet, and/or lower legs, flushing or redness of face (occurring without any signs of an allergic reaction). Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. How to use the study? Gutman AB "Uricosuric drugs with special reference to probenecid and sulfinpyrazone." Probenecid is started at 250 mg orally twice daily and titrated up to 1000 mg twice daily in most patients and occasionally up to 3 g daily if tolerated. Disclaimer: This information is independently developed by CIMS based on probenecid from various references and is provided for your reference only. It increases plasma levels of weak organic acids (e.g. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. This content does not have an Arabic version. You may report them to the FDA. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Arch Pathol 94 (1972): 241-3, 7. Probenecid (PROB) has been widely used for long time for different clinical purposes, from gout treatment to designs as a coadjutant for antibiotic agents. It may also be used to increase the levels of certain types of antibiotics in the blood. Applies to colchicine/probenecid: oral tablet. Nausea 5. Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. Probenecid also acts on the kidney to prevent certain antibiotics, such as penicillin, from being passed in the urine. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). 4. Side effects What should I do? Probenecid Side Effects. In one patient, a generalized rash, fever, malaise, and anorexia were also present. Take this medicine again only if your doctor advises you to do so. J Rheumatol 13 (1986): 208-9, 6. Common side effects of probenecid include the following: headache; dizziness; worsening of a gouty arthritis attack; vomiting; nausea; loss of appetite; sore gums; increased urination; fever; itching; hair loss; skin rash; This is not a complete list of probenecid side effects. What should I watch for? Probenecid/Colchicine Side Effects Nausea, cramping, diarrhea, loss of appetite, dizziness, hair loss, headache, vomiting, and frequent urination may occur. Drug information provided by: IBM Micromedex. Probenecid may be prescribed in combination with certain antibiotics (such as penicillins). Kickler TS, Buck S, Ness P, et al "Probenecid induced immune hemolytic anemia." What should I watch for? Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. Medically reviewed by Drugs.com. Along with its needed effects, a medicine may cause some unwanted effects. Adv Pharmacol 4 (1966): 91-142, 2. Probenecid (former brand name Benemid) is a drug prescribed for the treatment of gout and kidney stones. It is best to drink a full glass of water with each dose and at least another 8 glasses (8 ounces each) a day while taking this drug in order to prevent kidney stones. What are some side effects that I need to call my doctor about right away? Last updated on Sep 1, 2020. What are doable unwanted effects associated with probenecid (Benemid)? Some people also complain about hallucinations, confusion, agitation, and fear of impending death. Some rare side effects are convulsions, abdominal tenderness, stomach cramps, mental depression, yellow skin, sore throat, and unusual bleeding. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. All rights reserved. The following is a list of possible side-effects that may occur in medicines that contain Probenecid. Although not all of these side effects may occur, if they do occur they may need medical attention. 5. Your doctor will advise on any dose changes that are necessary. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Although not all of these side effects may occur, if they do occur they may need medical attention. Sosler SD, Behzad O, Garratty G, et al "Immune hemolytic anemia associated with probenecid." Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Probenecid and colchicine is a combination of a uricosuric agent and an antigout agent used to prevent gout attacks. Contact your prescriber if any of these side effects occur. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Along with its needed effects, a medicine may cause some unwanted effects. Probenecid / Colchicine Side Effects. Dosing recommendations and side effects. Headache 4. Visit your doctor or health care professional for regular checks on your progress. Mayo Clinic facts about coronavirus disease 2019 (COVID-19), Our COVID-19 patient and visitor guidelines, plus trusted health information, Mayo Clinic Health System patient vaccination updates. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects … Medically reviewed by Drugs.com. Consumer; Side effects; Professional; For the Consumer. Am J Clin Pathol 84 (1985): 391-4. Aspirin and non-steroidal antiinflammatory drugs like ibuprofen can make this medicine less effective. Portions of this document last updated: Feb. 01, 2021. Drug information provided by: IBM Micromedex. This is not a comprehensive list. Ann Rheum Dis 27 (1968): 249-52, 8. All rights reserved. It increases the levels of antibiotic in the blood, which helps the antibiotic work better. Side Effects. M04AB01 - probenecid ; Belongs to the class of preparations increasing uric acid excretion. Drug interactions. The risk for urolithiasis with potent uricosuric monotherapy such as probenecid and benzbromarone can be 9% to 11%. Your doct… Last updated on Nov 20, 2020. ... Life-threatening side effects such as thrombocytopenia, hemolytic anemia, leukemia and encephalopathy are extremely rare. "Product Information. This content does not have an English version. This site complies with the HONcode standard for trustworthy health information: verify here. USES: This medication is used to prevent gout and gouty arthritis.It will not treat a sudden/severe attack of gout and may make it worse. You may report side effects to Health Canada at 1-866-234-2345. It is used to treat and prevent gout. What are the possible side effects of colchicine and probenecid? Probenecid Side Effects Nausea, loss of appetite, dizziness, vomiting, headache, sore gums, or frequent urination may occur as your body adjusts to the medicine. Used in the treatment of gout. The study is based on allopurinol and probenecid (the active ingredients of Allopurinol and Probenecid, respectively). If you do experience side effects a reduction in dose may minimise these so that you can continue to take the medicine. These side effects may go away during treatment as your body adjusts to the medicine. Often side effects improve as your body gets used to the new medicine. Possible side effects. Consult your doctor if you observe any of the following side-effects, especially if they do not go away. penicillins, cephalosporins, or other β-lactam antibiotics) by competitively inhibiting their renal tubular secretion. Myers KW, Katial RK, Engler RJM "Probenecid hypersensitivity in AIDS: a case report." Ann Allergy Asthma Immunol 80 (1998): 416-8, 3. Decreased Appetite 3. Dosage of drugs is not considered in the study. Acute Inflammation Of The Joints Due To Gout Attack 2. [Ref], Rarely (less than 0.1%): Aplastic anemia, leucopenia, thrombocytopenia, Frequency not reported: Anemia, hemolytic anemia (which could be related to genetic deficiency of glucose-6-phosphate-dehydrogenase (G6PD) in red blood cells)[Ref], Frequency not reported: Anorexia, nausea, vomiting, sore gums[Ref], Rare (less than 0.1%): Hepatic necrosis[Ref], Frequency not reported: Headache, dizziness[Ref], Rare (less than 0.1%): Toxic epidermal necrolysis (in combination with colchicine), Frequency not reported: Dermatitis, alopecia, flushing[Ref], 1. Probenecid (probenecid)." Hertz P, Yager H, Richardson JA "Probenecid-induced nephrotic syndrome." This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Although not all of these side effects may occur, if they do occur they may need medical … Are There Any Other Precautions Or Warnings For This medication? Advertising revenue supports our not-for-profit mission. Remember, some side effects will go away without any treatment, but on other occasions, you may have to discuss it with your healthcare … Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. There may be an adverse effect on the liver after taking Probenecid. eHealthMe makes it possible for everyone to run personal clinical trial. Probenecid should not be taken in some blood disorders or if you have had uric acid kidney stones. Colchicine / probenecid Side Effects. What are the possible side effects of colchicine and probenecid? Side Effects. Along with its needed effects, probenecid may cause some unwanted effects. Call your doctor for medical advice about side effects. prednisone, allopurinol, triamcinolone, dexamethasone, betamethasone, Decadron, febuxostat, Uloric, Zyloprim, probenecid. puffiness or swellings of the eyelids or around the eyes, shortness of breath, troubled breathing, tightness in chest, or wheezing, changes in the skin color of the face occurring together with any of the other side effects listed here, or skin rash, hives, or itching occurring together with any of the other side effects listed here, lower back or side pain (especially if severe or sharp), skin rash, hives, or itching (occurring without other signs of an allergic reaction), sores, ulcers, or white spots on lips or in mouth, sore throat and fever with or without chills, swelling of face, fingers, feet, and/or lower legs, flushing or redness of face (occurring without any signs of an allergic reaction). If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Along with its needed effects, probenecid may cause some unwanted effects. Probenecid should not be used in children younger than 2 years. The study is created by eHealthMe based on 334 reports from the FDA, and is updated regularly. What about other medications? Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. It may take several months before you see the full effect of this medicine. Available for Android and iOS devices. Moderate. Probenecid belongs to a class of drugs known as uricosurics. Side effects requiring immediate medical attention. Vomiting It is only effective if you keep taking it regularly even if you have an attack of gout. Common side effects of probenecid and colchicine include nausea, vomiting, stomach pain, cramping, diarrhea, loss … Probenecid side effects (334 reports) How the study uses the data? Although not all of these side effects may occur, if they do occur they may need medical attention.