The identified studies had shortcomings related to restricted patient groups, lack of a control group, randomization, or blinding. Gastrointestinal effects, including nausea and vomiting, appear to be the most frequently reported adverse effect seen with the long-acting GLP-1 receptor agonists . Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. A frequent side effect of glucagon is nausea and/or vomiting. You are encouraged to report negative side effects of Prescription drugs to the Food and Drug Administration (FDA). Tell us what you think. Common side effects include blood glucose decreased among females and blood glucose decreased among males. • Serious allergic reactions. Brand Names: US Baqsimi One Pack; Baqsimi Two Pack; GlucaGen Diagnostic; GlucaGen HypoKit; Gvoke HypoPen 1-Pack; Gvoke HypoPen 2-Pack; Gvoke PFS Brand Names: Canada Baqsimi; GlucaGen; … Glucagon is contraindicated in patients with known hypersensitivity to it or in patients with known pheochromocytoma. Side effects like nausea, vomiting, and headache are pretty common. Glucagon can cause high blood pressure in certain people with tumors in their adrenal glands. Precautions Before using glucagon , tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies . Glucagon This information from Lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Glucagon is a peptide hormone, produced by alpha cells of the pancreas.It works to raise the concentration of glucose and fatty acids in the bloodstream, and is considered to be the main catabolic hormone of the body. Glucagon should be kept in its original container, and not opened until it is needed. Glucagon may cause serious side effects, including: • High blood pressure. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Glucagon is used during an MRI to slow down the motion in the bowels. Side effects may include nausea and vomiting, a temporary increase in heart rate, and allergic reactions to Glucagon or to one of the inactive ingredients in Glucagon. These side effects occur early on in the treatment, but tend to be transient and rarely result in patient withdrawal (24,32,36–39,41). Side effects specifically related to glucagon injection include skin discoloration, numbness, pain or tingling, and redness at the injection site. Side effects specifically related to nasal glucagon include a runny nose and nasal congestion, and head and facial discomfort. Glucagon Adverse reactions/side effects. The patient should regain consciousness in less than 15 minutes. You may report side effects to Health Canada at 1-866-234-2345. Your feedback will help us improve the information we provide to patients and caregivers. The most common side effects associated with glucagon for injection are nausea and vomiting, a temporary increase in heart rate, as well as redness and swelling of the injection site. WARNINGS. The most common side effects or adverse events associated with GLP-1 therapy is nausea, and occasionally vomiting, followed by diarrhea/constipation. We identified no properly conducted randomized clinical trials. Severe side effects are very rare, although nausea and vomiting may occur occasionally. Its effect is opposite to that of insulin, which lowers extracellular glucose. You may report side effects to Health Canada at 1-866-234-2345. Glucagon is only effective for 90 minutes and is to be used only until the patient is able to swallow. Most common adverse reactions (ARs) in > 2% of adult patients Gvoke 1 mg dose (N=154) Nausea: 30%: Vomiting: 16%: Injection site edema (raised ≥1 mm) 7%: Headache: 5%: ARs occurring within 12 hours. 81% of ARs were mild in adult patients 1. Glucagon should be administered with caution in patients with a history of insulinoma and/or pheochromocytoma. The average patient age was 13.8 ± 2.5 years (range = 10–17 years). Hemodynamic effects of glucagon have been investigated mainly in cohort studies of patients suffering from heart failure receiving large glucagon bolus injections. In rare cases, glucagon medications can cause allergy symptoms, such as rash, itching, respiratory issues and low blood pressure. Glucagon should be administered cautiously to patients with a … No severe side effects were seen in clinical trials. If you become unconscious, you need someone calm enough to be able to give you Baqsimi (glucagon). Description: Glucagon is an endogenous polypeptide hormone produced by the α cells of the pancreatic islets of Langerhans. • Low blood sugar. Rare side effects of glucagon include: Necrolytic migratory erythema (NME), a rash typically associated with a specific type of pancreatic cancer called a... Allergic reactions Anxiety Abdominal pain Changes in heart rate or blood pressure, particularly causing a rapid heartbeat. After injection of glucagon, the patient must be turned on their side to avoid choking. Glucagon side effects may include nausea and vomiting. CONTRAINDICATIONS . However, these are also symptoms of hypoglycemia for which synthetic glucagon may be used. Basqimi nasal powder is used to treat severe hypoglycemia in people with diabetes. A separate cohort of 50 pediatric patients, including 24 (48%) girls and 26 (52%) boys, were monitored for side effects by departmental nursing staff after standardized injection of glucagon. Glucagon Drug interactions. However, the clinical development of several glucagon receptor antagonists (GRAs) has been discontinued because of side effects, including hepatic steatosis and increased concentrations of total cholesterol, LDL cholesterol, and hepatic transaminases (26–28), combined with concerns about α-cell hyperplasia in preclinical studies . Indomethacin may produce hypoglycaemia. Gastrointestinal side effects. Glucagon may cause side effects. Incompatible in solution with most other substances. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Common side effects may include: nausea, vomiting; or swelling where an injection was given. Side effects are reported by people who take Glucagon. It is also used as a medication to treat a number of health conditions. Back to top. If you experience any other reactions which are likely to have been caused by glucagon, please contact your doctor. Dizziness, headache, hypertension, tachycardia, nausea, vomiting, rebound hypoglycemia. Three preparations of glucagon ar The aim of this study was examine the mechanism of the inhibitory effect of glucagon on gastrointestinal motility and the cause of its side effects by comparing three glucagon preparations. Some of the more common side effects include: Nausea Vomiting Diarrhea No significant drug interactions with other emergency medications. The study is created by eHealthMe based on 2,617 reports from the FDA, and is updated regularly. If you have questions about your care, contact your … (17) However, it is essential to keep in mind that nausea and vomiting are also two of the common symptoms of severe hypoglycemia. Learn how it compares to glucagon injections, including side effects. May enhance the anticoagulant effect of warfarin. Glucagon may cause side effects. We read every comment, but we're not able to respond. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. What are the side effects? of glucagon in combination with anticholinergic drugs may result in increased side effects, the use of glucagon in combination with anticholinergic drugs is not recommended. WARNINGS . 1-mg powder in vials (requires reconstitution with diluent provided). Occasional nausea and vomiting. Tell your doctor if any of these symptoms are severe or do not go away: nausea; vomiting; hives; injection site swelling or redness; headache; fast heartbeat; Some side effects can be serious. Anticholinergic drugs may increase GI reactions. See Important Safety Information and Full Prescribing Information. Some people have reported experiencing nausea and vomiting after being given injectable glucagon. Where should glucagon be stored? This enables us to obtain clearer pictures of the stomach and pelvis areas. A sugar source should be given when the patient regains consciousness. Tell us what you think . See common side effects and safety information for Gvoke® (glucagon injection). Glucagon Emergency Kit Side Effects Nausea, vomiting, or headache may occur. Action . IV Glucagon and Patient Tolerance. For the majority of subjects, the extent of nausea generally diminishes over time, and most subjects do not report ongoing nausea after several months of therapy with a GLP-1 R agonist. Common side effects Nausea (30%) Vomiting (16%) Injection site swelling (7%) Headache (5%) Irritation, redness, or swelling at the injection site may also occur. Glucagon administration caused phase III-like contractions in the duodenum and jejunum, which may be responsible for the side effects of glucagon. There are usually minor side effects of using glucagon. Since glucagon is a protein, hypersensitivity is a possibility. Demonstrated in pediatric patients 1. Insulin antagonises the effect of glucagon. The doctor must be called. Glucagon How supplied . Glucagon is a hormone made in the body that increases blood sugar levels. Demonstrated in adults 1. Most people don’t have any side effects. Glucagon can cause low blood sugar in patients with tumors in their pancreas called insulinomas and Glucagonomas by making too much insulin in their bodies. SIDE EFFECTS. Possible Side-Effects of Glucagon. If not, a second dose may be given. Side Effects. Precautions Before using glucagon , tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies . Some people may have nausea and vomiting after getting glucagon. eHealthMe is running one of the largest drug safety studies in the world. It is best to have a few doses of Baqsimi (glucagon) and keep them in different places since low blood sugar can happen anywhere and at … We study 17 million patients and 5,000 more each day. A few people may be allergic to glucagon or to one of the inactive ingredients in glucagon, or may experience rapid heart beat for a short while.