The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. May be used temporarily to reduce elevated uric acid levels caused by certain cancer treatments in people with leukemia, lymphoma, and other malignancies. May interact with a number of different drugs including mercaptopurine and azathioprine (the dosage of these two drugs needs to be reduced to approximately one-third to one-fourth of their normal dosage). It comes with serious risks if you don’t take it as prescribed. View complete list of side effects. Febuxostat oral tablet doesn’t typically cause drowsiness. Affected people should not drive or operate machinery. You can take febuxostat with or without food. It can take several months before you notice its effect. Never try to catch up by taking two doses at once. Pegloticase, given as an intravenous (in the vein) infusion. Don’t take this drug again if you’ve ever had an allergic reaction to it. Prevention Can I prevent gout? Studies suggest that vitamin C may…, Research has shown that certain compounds in celery seed may have benefits in treating gout. This is the most serious warning from the Food and Drug Administration (FDA). For people with other causes of high uric acid levels: If you have high uric acid levels associated with cancer or cancer treatments or with Lesch-Nyhan syndrome, this drug may not be a good option for you. Always discuss possible side effects with a healthcare provider who knows your medical history. © 2005-2021 Healthline Media a Red Ventures Company. This means you may need to take it with other medications. Examples of drugs that can cause interactions with febuxostat are listed below. Febuxostat oral tablet is used to treat hyperuricemia (constantly high levels of uric acid) in adults who have gout. Your goal is a uric acid level in your blood that is less than 6 mg/dL. This could result in dangerous side effects. This can be harmful or prevent the drug from working well. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. What to do if you miss a dose: Take your dose as soon as you remember. Important information about gout medication Don’t store this medication in moist or damp areas, such as bathrooms. If you experience these symptoms, call 911 or your local emergency services or go to the nearest emergency room. Allopurinol (Aloprim, Lopurin, ... treats chronic gout by lowering the uric acid produced in your body. It helps decrease symptoms of … This may make it difficult for your doctor to tell how this drug is affecting your liver. Hyperuricemia happens if there's too much uric acid in your blood. Monitoring is necessary for people with pre-existing liver disease and an investigation into the functioning of the liver should be conducted if symptoms such as weight loss or itchy skin develop. For children: This medication has not been studied in children. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. We look at bifocal contacts from dailies to longer wears and answer some of the most asked questions when it comes to multifocal contacts. Don’t worry about airport X-ray machines. Allopurinol may be taken once daily. Allopurinol reduces the production of uric acid (a compound produced by the body associated with gout and kidney stones), by inhibiting an enzyme called xanthine oxidase. Allopurinol belongs to the class of medicines called xanthine oxidase inhibitors. If you stop taking the drug suddenly or don’t take it at all: Your uric acid levels will likely remain high and continue to cause gout symptoms. So, as a precaution, it’s likely you’ll be prescribed a low-dose NSAID or colchicine to take on a daily basis for the first six months of starting febuxostat. This information is not a substitute for medical advice. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Febuxostat may cause a severe allergic reaction. How to tell if the drug is working: Your uric acid levels should decrease after about 2 weeks of taking febuxostat. Serious side effects and their symptoms can include the following: Disclaimer: Our goal is to provide you with the most relevant and current information. If your symptoms are severe, call 911 or your local emergency services or go to the nearest emergency room right away. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Xanthine oxidase is an enzyme that helps your body make uric acid from the substance xanthine. Not every pharmacy stocks this drug. Medicines that interact with allopurinol may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with allopurinol. Store febuxostat at room temperature between 59°F and 86°F (15°C and 30°C). Febuxostat comes only as a tablet you take by mouth. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use allopurinol only for the indication prescribed. If you have a history of cardiovascular disease, you should only use febuxostat to treat your gout in two situations. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. It is not unusual to experience a gout attack in the first few weeks of allopurinol initiation. Your dosage will depend on: Febuxostat has not been studied in children. Always carry your medication with you. In people with severe kidney disease, a dosage of 100 mg/day or 300mg twice a week may be sufficient to reduce high uric acid levels. The dosage of allopurinol needs reducing in people with kidney disease and their renal function monitored at least during the early stages of therapy. Medically reviewed by Carmen Fookes, BPharm. Many insurance companies require a prior authorization for this drug. For people with liver disease: This drug has not been studied in people with severe liver disease. Select one or more newsletters to continue. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Allopurinol is a maintenance treatment for gout or high uric acid levels so it should be taken regularly even once a gout attack has resolved. For people with cardiovascular disease: If you have a history of cardiovascular disease, you should only use febuxostat to treat your gout in two situations. Symptoms of gout include pain, swelling, redness, heat, soreness, and stiffness in certain joints. Talk to your doctor if you’re pregnant or planning to become pregnant. Rarely, may cause bone marrow depression. Febuxostat also may increase the risk of heart-related death. May also be used to treat recurrent kidney stones (calcium oxalate calculi) in males with a urinary uric acid level of more than 800 mg/day, or in females with levels greater than 750 mg/day. A boxed warning alerts doctors and patients about drug effects that may be dangerous. Don’t put this medication in your car’s glove compartment or leave it in the car. The major metabolites of caffeine can be found excreted in the urine. Talk to your doctor if you breastfeed your child. Keep these considerations in mind if your doctor prescribes febuxostat for you. They can’t harm your medication. Febuxostat may interact with other medications, Important considerations for taking febuxostat, Hyperuricemia: Symptoms, Treatment, and More, Best Diet for Gout: What to Eat, What to Avoid. Some may be better suited for you than others. Allopurinol may be better tolerated if taken with food. Just continue taking allopurinol as scheduled. For people with severe kidney disease: If you have severe kidney disease, talk to your doctor about whether this drug is right for you. Febuxostat belongs to a class of drugs called xanthine oxidase inhibitors. Febuxostat, taken as a pill. If you become pregnant while taking this drug, call your doctor right away. Allopurinol, taken as a pill. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The more common side effects of febuxostat can include: If these effects are mild, they may go away within a few days or a couple of weeks. Starting with a low dose of allopurinol and febuxostat is strongly recommended over starting at a higher dose. All rights reserved. Always speak with your doctor or pharmacist about dosages that are right for you. To help prevent this, your doctor may prescribe NSAIDs, colchicine, or steroid tablets as well as allopurinol or febuxostat. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Learn what medications are available to help keep your symptoms under…. The second is if you’ve tried allopurinol and it was not effective enough for you. Keep it in your carry-on bag. Peak levels of allopurinol are reached within 1.5 hours and 4.5 hours for its active metabolite. Doing so can cause dangerous effects in your body. These drugs are often used to treat similar conditions. Occasionally may cause drowsiness. These substances may be in some of the foods you eat. If febuxostat isn't suitable for you, your doctor may suggest you take other medicines, such as sulfinpyrazone and benzbromarone. For pregnant women: Research is limited regarding the use of this drug in pregnant women. Allopurinol or febuxostat is strongly recommended over probenecid as a first-line treatment for patients with moderate-to-severe chronic kidney disease. Revision date: March 19, 2020. sodium bicarbonate, febuxostat, Uloric, Zyloprim, probenecid, rasburicase, Krystexxa, pegloticase, Elitek, Aloprim. A class of drugs is a group of medications that work in a similar way. Symptoms can include: If you develop these symptoms, call 911 or your local emergency services or go to the nearest emergency room. Other treatments (such as NSAIDs or colchicine) are usually prescribed to be taken during an acute gout attack. It helps decrease your symptoms of gout. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Here's what you need to know about the benefits, side…, The risk of getting COVID-19 from food or food packaging is low. You may need to show airport staff the pharmacy label for your medication. Allopurinol may be better tolerated if taken with food. sudden numbness or weakness in your face, arms, or legs, trouble seeing out of one or both of your eyes, sudden trouble walking, dizziness, or loss of balance or coordination, jaundice (yellowing of your skin or the whites of your eyes), swelling in the upper right part of your abdomen. For women who are breastfeeding: Febuxostat may pass into breast milk and cause side effects in a child who is breastfed. Your doctor should monitor certain health issues while you take this drug. Adjusting your diet is the most important way to…, A gout flare can be controlled with short-term and long-term medications. Call your doctor right away if you have serious side effects. Do not drive or operate machinery if allopurinol makes you drowsy or impairs your judgment. If you forget a dose of allopurinol, you do not need to double up the next dose. We comply with the HONcode standard for trustworthy health information -, Calcium Oxalate Calculi with Hyperuricosuria, https://www.drugs.com/ppa/allopurinol.html. Disclaimer: Our goal is to provide you with the most relevant and current information. Last updated on March 20, 2020. Just continue taking allopurinol as scheduled. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it. The first is if you’re not able to take the gout drug allopurinol. This information is not a substitute for medical advice. It should not be used in children younger than 18 years. Febuxostat is used to lower uric acid levels in people with gout.Febuxostat works by reducing the amount of uric acid made by the body. It’s not available as a generic drug. Allopurinol is used in the treatment of high uric acid levels associated with gout, kidney stones, and cancer treatment. People administered allopurinol for high uric acid levels occurring as a result of cancer are at higher risk of developing kidney damage from allopurinol. 1,7-Dimethyluric acid; Route of elimination. May also cause diarrhea, nausea, and laboratory test changes. Febuxostat oral tablet can interact with other medications, vitamins, or herbs you may be taking. Call your doctor right away if you have worsening symptoms of gout, or if your gout symptoms don’t get better after six months of treatment with febuxostat. The use of pegloticase is strongly recommended against as a first-line treatment. Can Different Parts of the Celery Plant Naturally Treat Gout? Seek immediate medical advice if unexplained weight loss or itchiness develop while you are taking allopurinol. You should not need a new prescription for this medication to be refilled. This can help make sure you stay safe during your treatment. May cause a skin rash which may be a sign of an allergic reaction to allopurinol. Uric acid levels. Probenecid, taken as a pill. For this drug to work well, a certain amount needs to be in your body at all times. Taking febuxostat places you at a much greater risk of cardiovascular death than taking allopurinol. A prescription for this medication is refillable. 12 About 0.5% to 2% of a caffeine dose is found excreted in urine, as it because it is heavily absorbed in the renal tubules. If you forget a dose of allopurinol, you do not need to double up the next dose. Call 911 or your local emergency services if your symptoms feel life-threatening or if you think you’re having a medical emergency. However, it can cause other side effects. Your symptoms of gout should also go away. Your doctor may check your levels of uric acid two weeks after starting febuxostat.
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